1630 - 1710 Christopher J Chang

Metals on the Brain: Probing Cellular Chemistry with Molecular Imaging 

The brain needs among the highest levels of copper and iron in the body for normal function, but misregulation of these redox-active metals is connected to oxidative stress cascades that occur with aging and age-related neurodegenerative diseases. We have initiated a broad-based program to study the complex roles of metal ions [1-5] and redox biology [6-9] in brain health, aging, and disease by creating new fluorescent and MRI indicators to track metal ions and oxygen metabolites in living cells, tissue, and organisms. The design, synthesis, and evaluation of our most recent platforms and their use in molecular imaging will be presented. 

[1] Zeng, L.; Miller, E. W.; Pralle, A.; Isacoff, E. Y.; Chang, C. J. J. Am. Chem. Soc. 2006, 128, 10-11. 

[2] Domaille, D. W.; Zeng, L.; Chang, C. J. J. Am. Chem. Soc. 2010, 132, 1194-1195. 

[3] Que, E. L.; Gianolio, E.; Baker, S. L.; Wong, A. P.; Aime, S.; Chang, C. J. J. Am. Chem. Soc. 2009, 131, 8527-8536. 

[4] Que, E. L.; Domaille, D. W.; Chang, C. J. Chem. Rev. 2008, 108, 1517-1549. 

[5] Domaille, D. W.; Que, E. L.; Chang, C. J. Nature Chem. Biol. 2008, 4, 168-175. 

[6] Chang, M. C. Y.; Pralle, A.; Isacoff, E. Y.; Chang, C. J. J. Am. Chem. Soc. 2004, 126, 15292-15293. 

[7] Miller, E. W.; Tulyathan, O.; Isacoff, E. Y.; Chang, C. J. Nature Chem. Biol. 2007, 3, 263-267. 

[8] Miller, E. W.; Chang, C. J. Curr. Opin. Chem. Biol. 2007, 11, 620-625. 

[9] Dickinson, B. C.; Chang, C. J. J. Am. Chem. Soc. 2008, 130, 9638-9639.