Conferences and Events
S206_001 Protein epitope mimetics in drug and vaccine research (KEYNOTE)
John A. Robinson*
S206_002 The stereoselective synthesis of iodinated analogues of reboxetine for SPECT imaging of the noradrenaline transporter
Nicola K. Jobson, Andrew R. Crawford, Deborah Dewar, Sally L. Pimlott, Andrew Sutherland*
S206_003 Enantioselective synthesis of -carboline and isoquinoline derivatives via the asymmetric transfer hydrogenation
Stefan J. Czarnocki, Dawid Lichosyt, Joanna Szawkao, Piotr Roszkowski, Zbigniew Czarnocki*
S206_004 Novel pyrazoline and pyrazole amino acids by 1,3-dipolar cycloaddition
Raymond C. F. Jones*, Laura E. Seager
S206_005 Towards the total synthesis of the ajmaline family of indole alkaloids
Tess Phillips*, Patrick Bailey, Mark Beard, Hoa Dang
S206_006 Nitrogen heterocycles a versatile class for antiparasitic chemotherapy (KEYNOTE)
P.M.S. Chauhan*
S206_007 Stereoselective synthesis of Aza CMI-977, a potential lead candidate for chronic asthma
Mukund S. Chorghade*, Anjali M. Rahatgaonkar
S206_008 Abstract Withdrawn
S206_009 Asymmetric synthesis of highly substituted piperidines as kappa opioid receptor antagonists
Daniel P. Furkert, Faye A. Bradbury, John R. Traynor, Stephen M. Husbands*
S206_010 The discovery of Sugammadex (Bridion®)
Helen Feilden*
S206_011 Cyclization, catenation and PCR amplification of DNA ligated by click chemistry (KEYNOTE)
Afaf H. El-Sagheer, Nittaya Gale, Petr Kocalka, Tom Brown*
S206_012 An improved direct synthetic approach to anhydronucleosides
Alya M. El-Etaibi, A. Al El-Ibtehal-Juwaiser, Maher R. Ibrahim, Nouria A. Al-Awadi*
S206_013 Hydrogen bonding and hydrophobic interactions in highly potent antibacterial minor groove binders
David Breen*, Colin J. Suckling
S206_014 PK/PD optimization of dihydropyridine allosteric FSH-R agonists
Cornelis M. Timmers*
S206_015 Recent progress in the total synthesis of gambieric acid A, a marine polyether with potent anti-fungal activity
J. Stephen Clark*, Jérôme Molette, Alister Stewart, Bora Sieng, Marc Kimber
S206_016 Defining the druggable cysteinome (KEYNOTE)
Jack Taunton*
S206_017 Development of potent inhibitors of the DNA-dependent protein kinase (DNA-PK)
Celine Cano*, Nicola J. Curtin, Bernard T. Golding, Ian R. Hardcastle, Herbie Newell, Julia Bardos, Graeme C. M. Smith, Roger J. Griffin
S206_018 Synthesis of Novel 2-pyrazolines
Geeta J. Pant*, Pramod Singh, Jagmohan S. Negi, Asha Budakoti, Mohan S. M. Rawat
S206_019 Discovery of SCH 530348 - A Thrombin Receptor Antagonist (TRA) with Potent Antiplatelet Activity
Samuel Chackalamannil*, Yuguang Wang, William J. Greenlee, Mariappan Chelliah, Martin Clasby, Keith Eagen, Zhiyong Hu, Yan Xia, Ho-Sam Ahn, George Boykow, Madhu Chintala
S206_020 The iso-seco-tanapartholides: isolation, synthesis and biological evaluation
E. F. Makiyi, R. F. M. Frade, T. Lebl, E. G. Jaffray, S. E. Cobb, A. L. Harvey, A. M. Z. Slawin, R. T. Hay*, Nicholas J. Westwood*
P206_001 Pyridine stretched oligonucleotides (PSOs) Michael L. Davis, William Fraser*, Christopher A. Ramsden
P206_002 Synthesis of 2,3-substituted maleimides by chemoselective palladium-catalyzed cross-coupling reactions of indium organometallics Latifa Bouissane*, José Pérez Sestelo, Luis A. Sarandeses
P206_003 Stereoselective oxanorbernenyl routes to hydroxylated cyclohexyl -amino acid derivatives Ishmael B. Masesane*, Patrick G. Steel
P206_004 Pharmocological study of biotransformation of substituted and unsubstituted indanone acetic acid adduct with pyrazolone ring for analgesic activity in-vivo Nirali A. Passi*, Dhrubo Jyoti Sen, Indermeet Singh Anand
P206_005 APT inhibition of Clostridium difficile Kate Bodley, William Fraser*, Peter A. Lambert
P206_006 The discovery of 3-carboxamide isoxazoles as TRPV1 antagonists for the treatment of pain Ronald Palin*
P206_007 Synthesis of new lariat ethers containing polycyclic phenols and heterocyclic aromatic compound Hashem Sharghi, Reza Khalifeh*, Alireza Salimi Beni
P206_008 A New synthesis of functionalized 1-azadienes Bita Mohtat*, Issa Yavari, Hoorieh Djahaniani
P206_009 An expeditious microwave-assisted synthesis of -pyrimidinyl-,-didehydro--amino acid derivatives Jure Hren, Franc Pogan, Slovenko Polanc, Marijan Koevar*
P206_012 Chemical and biological investigation into the aerial shoot of Cissampelos capensis Olalekan J. Babajide*, Wilfred T. Mabusela, Ivan R. Green, Emmanuel I. Iwuoha
P206_013 Synthesis of benzisoxazoles by the [3 + 2] cycloaddition of oxaziridines with arynes Arif Kivrak*, Richard C. Larock
P206_014 Synthesis of heterocyclic compounds containing the adamantyl radical Gennadiy M. Butov*, Vladumir M. Mokhov, Karim R. Saad
P206_015 Gas-phase thermolysis of 1,2,3-triazole and 1,2,3-triazine derivatives H. Al-Awadi, M. R. Ibrahim, N. Al-Awadi, Y. A. Ibrahim*
P206_016 p-toluenesulfonic acid catalyzed a novel one-pot synthesis of spirooxindoles Maliheh Khorshidi*, Majid M. Heravi
P206_017 A convergent approach to modifying the C-ring of prodigiosenes Alison Thompson*, Sarah Bennett
P206_018 Synthesis and antimicrobial properties of novel anionic heterocyclic surfactant derivatives of 5-alkyl-2-methyl-1,3-thiazol Akihiro Shirai, Yasuko Fumoto, Shou Nashino, Hideaki Maseda, Hiroki Kourai*
P206_019 The series of novel, potential quinoline and phenylpiperazine based histone deacetylase inhibitors Olga Habarova*, Daina Lola, Einars Loza, Viktor Andrianov, Olga Bobileva, Fredrik Björkling
P206_020 Chemical pathways for the synthesis of TRIS-based bis(oxazolidines) Sabrina Elise*, Jimmy Sélambarom, Jacqueline Smadja
P206_021 One pot synthesis of stable phosphorus ylide using trialkyl phosphites and acetylenic diesters in the presence of NH-containing compounds Morteza Ziyaadini-Avarani*, Mohsen Rostamizadeh, Malek T. Maghsoodlou
P206_022 Study of hantzsch synthesis reaction in the preparation of a novel dihydropyridine C-Glycosylated compound Soheila Sedaghat*, Shabnam Madjdpour, Eskandar Alipour
P206_024 Synthesis of some thienopyrimidinone and triazolothienopyrimidinone derivatives as potential DNA intercalators and antimicrobial agents Ahmed M. Farghaly, Ragab M. Shafik, Adnan A. Bekhit, Mona M. A. Elsemary*, Alaa El-Din A. Bekhit, Mai S. El-Shoukrofy
P206_025 Absolute configuration of axially chiral 4,4-bisquinolones Walter M. F. Fabian*, Sajid Jahangir, Georg Uray
P206_026 Synthesis of bis-pyrimido imidazole fused ring heterocyclic adduct with ureas of mannich base for CNS depression Dhrubo Jyoti Sen*, Avani H. Sheth, Yatri R. Shah, Parimal M. Prajapati
P206_027 Formazans: A novel class of potential biological agents B. C. Revanasiddappa*, Nagendra R. Rao, E. V. S. Subrahmanyam
P206_028 Discovery of inhibitors for Plasmodium falciparum N-Myristoyl Transferase: An antimalarial Target Zhiyong Yu, Edward W. Tate, Robin J. Leatherbarrow*
P206_029 Potent antitumor DNA alkylating 1,2-bis(hydroxyl-methyl)-3a-aza-cyclopenta[a]-indenes, synthesis and antitumor activity Tsann-Long Su*, Rajesh Kakadiya, Naval Kapuriya, Xiuguo Zhang, Ting-Chao Chou
P206_030 Sequential five-component synthesis of spiropyrrolidinochromanones Ana G. Neo, Rosa M. Carrillo, Stefano Marcaccini, Carlos F. Marcos*
P206_031 Synthesis of selenolo[3,2-c]pyrazole analogs of 1-Benzyl-3-(5-hydroxymethyl-2-furyl)indazole (YC-1) as novel anti-cancer agents Sheng-Chu Kuo*, Li-Chen Chou, Li-Jiau Huang, Mei-Hua Hsu, Mei-Chi Fang, Jai-Sing Yang
P206_032 Synthesis and evaluation of antioxidant properties of some 2-[2-(4-chlorophenyl)benzimidazol-1-yl]-N-(4-oxo-2-substitutedphenyl-thiazolidin-3-yl)acetamides Gülgün Ayhan-Kilcigil*, Selen Gürkan, Tülay çoban, Elçin Deniz Özdamar, Benay Can-Eke
P206_033 Conventional and solvent free syntheses of 1N-3-{(4-substituted aryl-3-chloro-2-oxo-azetidine)-imido}-propyl-1,2,3 -benzotriazole derivatives: Antimicrobial activity Ritu Sharma, S. D. Srivastava*
P206_034 Application of heteropolyacids as heterogeneous and recyclable catalysts for one-pot synthesis of 3-cyanopyridine derivatives Yahya Beheshtiha*, Maliheh Khorshidi
P206_035 A convenient synthesis of bis (Indol) alkanes by niobium (V) chloride Majid M. Heravi*, Fatemeh Nahavandi
P206_036 Syntheses of salinosporamide a and A-315675 via Overman rearrangement Takayuki Momose*, Naoto Hama, Chiharu Higashino, Yuji Kaiya, Jun-ichi Hasegawa, Takaaki Sato, Noritaka Chida
P206_037 Design and synthesis of azaisoflavones and their inhibitory activities of NO production in activated microglia Guo Hua Jin, Semi An, Sang Keun Ha, Sun Yeou Kim, Jae-Ha Ryu, Raok Jeon*
P206_038 Retention of symmetry vs. desymmetrization of bicyclo[2.2.2]octenes with the assistance of a bridgehead amide group Jure Hren*, Franc Perdih, Slovenko Polanc, Marijan Koevar
P206_039 From diazenes to structurally similar amides: a path towards new D-alanine-D-alanine ligase inhibitors Vita Majce*, Andreja Kova, Stanislav Gobec, Marijan Koevar, Slovenko Polanc
P206_040 Synthesis and biological activity of some new substituted purine derivatives in human cancer cells Meral Tunçbilek*, Zeynep Demir, Rengül Atalay
P206_041 Synthesis of azo-appended pyrrole polyamides for DNA binding and photocleavage Chi-Wi Ong, Meng-Chi Liu*, Ping Hao Liu
P206_042 Use of small ring activation in the synthesis of highly fuctionalised heterocycles Hayley T.A. Watson*, Steve D. R. Christie, Julie C. Reilly
P206_043 Synthesis and antimicrobial evaluation of some new substituted purine derivatives Meral Tunçbilek, Zeynep Ate-Alagöz, Nurten Altanlar*
P206_045 Discovery of 3-carboxamides as TRPV1 antagonists for the treatment of pain Tom R. Clarkson*, et al
P206_046 The discovery of novel CB1 receptor antagonists Tom R. Clarkson*, et al
P206_047 Synthesis, spectroscopic, mass spectrometry and semi-empirical studies of new type aminoalkyl-2,3-unsaturated derivatives of 16-membered natural macrolide antibiotic - Josamycin Piotr Przybylski*, Krystian Pyta, Bogumil Brzezinski
P206_048 Remote control of the diastereoselectivity in The Pauson-Khand reactions of camphor-derived enynes Serdar Sezer*, Yasemin Gümrükçü, Cihangir Tanyeli
P206_049 The discovery of 3-carboxamide isoxazoles as TRPV1 antagonists for the treatment of pain Lesley Nisbet
P206_050 The discovery of novel TRPV1 antagonists for the treatment of pain Anna-Marie Easson
P206_051 Structure- based design and synthesis of xanthones as potential inhibitors of steroid sulfatase Elisangela V. Costa*, Maria E. Sousa, Josmar da Rocha, Carlos A. Montanari, Madalena M. Pinto
P206_052 Diversity oriented synthesis and structure based design in the discovery of anti-infective compounds Judith K. Huggan*, Colin L. Gibson, Colin J. Suckling, Jeong-Hwan Lee, Jonathan Adcock
P206_053 Molecular iodine promoted synthesis of new pyrazolo[3,4-d]pyrimidine derivatives as potential antibacterial agents Mehdi Bakavoli*, Ghodsieh Bagherzadeh, Maryam Vaseghifar, Ali Shiri, Mehdi Pordel, Mansour Mashreghi, Parvaneh Pordeli, Maryam Araghi
P206_054 N-Nitrosocarbamates in the synthesis of 3-(2-aminoethyl)imidazotetrazines Elrashied A. E. Garelnabi*, Dimitrios Pletsas, Richard T. Wheelhouse
P206_055 Synthesis and Properties of 1,3-X,N-heterocycles for topical drug delivery Audrey Martinez*, Jimmy Sélambarom, Christine Robert-Da Silva, Claude Rouch, Yann Pellequer, Alf Lamprecht
P206_056 New synthesis of benzo[1,2,3]thiadiazine 1,1-dioxides Márta Porcs-Makkay*, László Pongó, Gyula Simig
P206_057 Approaches to atropoisomeric N-heterocyclic natural products Benjamin R. Buckley, Steve D. R. Christie, Claire M. Gillings*, Philip C. Bulman-Page
P206_058 Efficient microwave-assisted synthesis and oxidative aromatization of Hantzsch 1,4-dihydropyridines Bruno F. O. Nascimento*, Marta Pineiro, António M. d A. Rocha Gonsalves
P206_059 Novel xanthine oxidase inhibitors: new treatment for gout Maria Leigh*, Anne-K. Duhme-Klair
P206_060 Novel [3 ¶ 2] and [4 ¶ 2] cycloaddition reactions on transition metal templates. Regio- and stereo-controlled routes to heterocycles Steven D. R. Christie*
P206_061 The iminohydantoin series of BACE1 inhibitors. Part 1: Design, discovery and initial optimization Brian McKittrick*, Zhaoning Zhu, Zhong-Yue Sun, Yuanzan Ye, James Durkin, Robert Mazzola, John Caldwell, Elizabeth Smith, Terry Nechuta, Jared Cumming, Lingyan Wang, Jianshe Kong, Tao Meng, Daniel Wyss, Allen Yu-Sen Wang, Mary Senior, Johannes Voigt, Corey Strickland, Matthew Kennedy, Xia Chen, Reshma Kuvelkar, Lenard Favreau, Eric Parker, Andrew Stamford, Vincent Madison, Michael Czarniecki, William Greenlee, John Hunter
P206_062 Synthesis of new heterocyclic compounds of 1,2,4-triazol-3-phenoxymethyl-5-thiones Corina Cerntescu, Rodica Diaconescu, Ana-Maria Grigoriu*, Anca Mocanu, Corneliu Oniscu, Nicoleta Vornicu, Cristina Bibire
P206_063 Modeling and optimization for the synthesis of new heterocyclic compounds by artificial neural networks Rodica Diaconescu, Corina Cerntescu, Ana-Maria Grigoriu*, Anca Mocanu, Corneliu Oniscu, Nicoleta Vornicu, Cristina Bibire
P206_065 1,3,4-thiadiazole and 1,2,4-triazole derivatives of 2,4-dichlorophenoxyacetic acid. Synthesis and preliminary evaluation of biological properties M.R. Aouad*, M. Bouchekara, N. Rezki, N. Aoumeur, E.S.H. El Ahsry
P206_066 Synthesis and antimicrobial evaluation of new 1,3,4-thiadiazoles and 1,2,4-triazoles derived from benzo[b]thiophene Aouad M. Reda*, Bouchekara Mohamed, Rezki Nadjet, Aoumeur Nabila, El Ahsry E. S. Helmi
P206_067 Convenient synthesis of 3-(Dialkylphosphono)chroman-2- and 4-ones Yoshiharu Okada, Hideyuki Fujimori*, Kei-ichiro Yoneya, Yusaku Kanna, Masato Nomura
P206_068 N-Arylation of nitrogen heterocycles with 2,4-difluoroiodobenzene Rukkiat Jitchati*, Andrei S. Batsanov, Martin R. Bryce
P206_069 A new rearrangement of isoxazole into pyrazole Maria V. Karabanova, Mikhail K. Korsakov, Mikhail V. Dorogov
P206_070 4-Hydroxylamino-avermectins and nitrones: Synthesis and biological activity Thomas Pitterna, Anton Scherrer, Melloney Tyte*
P206_071 The optimisation of novel isoxazolopyrimidine fungicides Eric D. Clarke, Russell G. Moulding, Melloney Tyte*, William G. Whittingham
P206_072 Milestones in the discovery of pinoxaden: A unique graminicide for global use in cereal crops M. Boeger, F. Cederbaum, D. Cornes, A.A. Friedmann, J. Glock, M. Muehlebach, T. Niderman, M. Tyte*
P206_073 Design and synthesis of novel ellipticine c-kit kinase inhibitors Charlotte M. Miller*, Damien Thompson, Florence O. McCarthy
P206_074 The iminohydantoin series of BACE1 inhibitors Jared Cumming*, Lingyan Wang, Elizabeth Smith, Xia Chen, Michael Czarniecki, Leonard Favreau, William Greenlee, John Hunter, Lynn Hyde, Ulrich Iserloh, Matthew Kennedy, Reshma Kuvelkar, Guoqing Li, Vince Madison, Brian McKittrick, Eric Parker, Andrew Stamford, Corey Strickland, Zhong-Yue Sun, Johannes Voigt, Yusheng Wu, Zhaoning Zhu
P206_075 Design and synthesis of novel bisaryl-5-aminopyrazole derivatives as potential anti-cancer agents Larry T. Pierce, Florence O. McCarthy
P206_076 Efficient and convenient preparation of novel -carbolinium derivatives El Sair R*, Ostler E.L
P206_077 Sequential metal-catalyzed N-heteroarylation and C–C Cross-coupling reaction: An expedient route to tris(hetero)aryl systems [1] Jamie S. Siddle, Andrei S. Batsanov, Martin R. Bryce
P206_078 Analogue-based drug discovery, Volume 2 Janos Fischer, C. Robin Ganellin, Mukund S. Chorghade*
P206_079 IUPAC subcommittee on medicinal chemistry and drug development C. Robin Ganellin, John Proudfoot, Mukund S. Chorghade*
P206_080 Discovery of NOP agonists as antitussive agents: From screening hit to clinical candidate Ginny D. Ho*, Ana Bercovici, Ahmad Fawzi, Xiomara Fernandez, William J. Greenlee, Robbie L. McLeod, Fay Ng, April Smith Torhan, Zeng Tan, Deen Tulshian, Xiaoying Xu, Hongtao Zhang
P206_081 Total synthesis of imidazole-containing natural products Carl J. Lovely*, Manoj Bhandari, Panduka Koswatta, Sabuj Mukherjee
P206_082 A comparative study of PEI for siRNA and DNA delivery Albert N. P. Kwok*, Aris Tagalakis, Jean McEwan, Stephan L. Hart
P206_083 A multi-component strategy for the synthesis of JNK inhibitors Manuel J. Díaz Mendoza, Lucía López-García, Ana G. Neo, Rosa M. Carrillo, Stefano Marcaccini, María Jesús Lorenzo, Edelmiro Momán, José M. Fuentes, Rosa A. González-Polo, Rubén Gómez-Sánchez, Sonia Martínez Caballero*, Carlos F. Marcos
