Oxygen Activation and Sensing by Iron in Biology

© W W Ho, H Li, C R Nishida, P R Ortiz de Montellano, T L Poulos, Crystal Structure and Properties of CYP231A2 from the Thermoacidophilic Archaeon Picrophilus Torridus, Biochemistry 47, 2071 2008

John Reglinski, University of Strathclyde, UK

Jon McMaster, University of Nottingham, UK

Emma Raven, University of Leicester, UK

Programme:

Wednesday 5 August (morning and afternoon)

Keynote Speakers

Pivotal intermediates in hemoprotein sensing and catalysis
Paul R. Ortiz de Montellano, University of California, USA

Explorations of the nonheme oxoiron(IV) landscape
Lawrence Que, Jr., University of Minnesota, USA

Speakers

Selectivity in cytochrome P450 oxidation: QM/MM studies
Jeremy Harvey, University of Bristol, UK

Structures of heme oxygenase catalytic intermediates
Masao Ikeda Saito, Tohoku University, Japan

The mechanism of iron core mineralisation in bacterioferritin
Nick E. Le Brun, University of East Anglia, UK

Hydrogen sulfide and heme-oxygen complex activation: The sulfheme scenario
Juan López-Garriga, University of Puerto Rico, USA

Oxygen activation and control in tryptophan 2,3-dioxygenase: New structural and mechanistic insights
Christopher G. Mowat, University of Edinburgh, UK

Rapid reduction of P450 enzymes by laser photexcitation of NAD(P)H
Andrew W. Munro, University of Manchester, UK

Bacterial and other microbial haemoglobins: roles in NO biochemistry
Robert K. Poole, University of Sheffield, UK

New roles for oxygenases catalysing post-translational modifications
Christopher J. Schofield, University of Oxford, UK

Symposium Information

Iron has a complex and intimate involvement in the function of almost all biological systems, its main roles being electron transfer, oxygen activation and biological catalysis. In all biological systems, iron exists either in the form of heme, as in hemoglobin and the cytochromes, or as non-heme iron, as in the mononuclear and binuclear iron enzymes. 

In this session, the role of iron in biological processes will be examined from the perspective of heme chemistry and non-heme chemistry, showing how this versatile element can access a wide range of chemistry, controlled by its oxidation state and protein environment.