25th Symposium on Medicinal Chemistry in Eastern England


24 April 2014
Fielder Centre, Hatfield

Session One

Chair - Dr Veronique Birault
GlaxoSmithKline 

James Day
Astex
From millimolar fragments to nanomolar antagonists of protein-protein interactions

Jeff McKenna
Novartis
NVS-CRF38 a novel CRF-1 receptor antagonist with favourable biopharmaceutical properties

Chris Swain
Cambridge MedChem Consulting
Bringing open source to drug discovery

Clive McCarthy
Evotec
Pan FGFR inhibitors with potent anti-tumour activity in mouse models of bladder cancer

Rick Roberts
Aimirall
CRTh2: Can residence time help?

Session Two

Chair - Professor Simon Ward
University of Sussex 

Capps-Green-Zomaya Award Presentation
Nicole Hamblin
GlaxoSmithKline
From bench to bedside: discovery and development of inhaled PI3 Kinase delta inhibitor GSK2269557 for the treatment of COPD

Thomas Hansson
AstraZeneca Molndal
Discovery of AZD5423, a potent and selective non-steroidal glucocorticoid receptor modulator for the inhaled treatment of respiratory diseases

David Pryde
Pfizer Neusentis
Design and synthesis of an anti-nicotine vaccine

Phil Jones
European Screening Centre Newhouse
The IMI European Lead Factory: new opportunities for drug discovery

John Christopher
Heptares
Structure-based drug discovery of dual antagonists of the Orexin-1 and Orexin-2 receptors

Sebastien Campos
GlaxoSmithKline
Development of irreversible ITK inhibitors as a potential new treatment for severe asthma

Some of these presentations are available to download.


Downloadable Files

Programme
24 April 2014, Fielder Centre, Hatfield, UK
PDF iconPDF (326k)  

Bringing open source to drug discovery
Chris Swain
PDF iconPDF (64k)  

Pan FGFR inhibitors with potent anti-tumour activity in mouse models of bladder cancer
Clive McCarthy
PDF iconPDF (724k)  

CRTh2: Can residence time help?
Rick Roberts
PDF iconPDF (1194k)  


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