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Arthritis drug found in mushrooms
04 July 2006
Mushrooms could play a pivotal role in the treatment of arthritis, suggest scientists in Germany and Vietnam.
Arthritis is a common chronic health problem, with rheumatoid arthritis affecting 1 in 50 people in the UK and gouty arthritis affecting 1 in 200. Drugs currently on the market can cause infrequent, but severe side effects.
Enzymatic processes control the inflammation of joints and tissues in arthritis. The researchers claim the compounds they have identified can block the enzymes that cause joints to become inflamed.
Hertweck and colleagues say the compounds they extracted from mushrooms show COX-2 and XO enzyme blocking activity similar to that of the leading drugs currently on the market.
H V K Wangun, A Härtl, T T Kiet and C Hertweck, Org. Biomol. Chem., 2006