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Shrinky DinkŪ microfluidics
05 December 2007
A children's toy has been turned into a microfluidic research tool in the hands of US engineers.
Michelle Khine's team from the University of California, Merced, printed microfluidic mould patterns onto Shrinky DinksŪ and used them to make patterns of channels for mixing fluids and moving cells about. The technique allows the whole process - from device design conception to working device - to be completed with very simple tools within minutes.
Shrinky DinksŪ are thermoplastic sheets of polystyrene which have been pre-heated and stretched. When they are reheated they shrink to their original size, also shrinking anything drawn on them. The drawn features become narrower and more raised as the ink lines are compressed.
Using only a laserjet printer and a toaster oven, the team printed a device layout on a Shrinky DinkŪ sheet and shrunk it down to make a mould. The ink lines printed on their Shrinky DinksŪ were raised by over 500% to form a series of small walls with slightly rounded edges, ideal for making channels for use with microfluidic valves. The polydimethylsiloxane plastic used to make the devices could then be simply poured onto the mould, cured, and peeled off.
'Many researchers are excited about this, because it dramatically lowers the barrier to entry into the microfluidics field,' said Khine. 'There are no tooling costs - all you need is a printer and a toaster oven.'
- Michelle Khine, University of California, Merced
'We are using the microfluidic chips for chemotaxis experiments and cell culture experiments,' she added, 'and we definitely have a couple more projects based on this in the oven.'
Link to journal article
Shrinky-Dink microfluidics: rapid generation of deep and rounded patterns
Anthony Grimes, David N. Breslauer, Maureen Long, Jonathan Pegan, Luke P. Lee and Michelle Khine, Lab Chip, 2008, 8, 170
Also of interest
Microfluidics research is expensive. Or is it? Canadian researchers have made prototype microfluidic chips using only a simple off-the-shelf wax printer.
Microfluidics meets analytical chemistry. Paul Bohn talks to Jenna Wilson about molecular transport in small channels.
US researchers have come up with a general strategy to integrate several biological steps in one microchip reactor.
The magical world of Shrinky DinksŪ
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