Chemical technology news from across RSC Publishing.
10 minute diagnosis on the microscale
15 April 2008
Scientists in the US have taken a step towards faster and more efficient immunoassays for diagnosing HIV and other diseases.
The microfluidic device can monitor interactions between an antigen and its antibody in real time
Richard Zare and colleagues from Stanford University have designed and constructed a new microfluidic device that can monitor immunoreactions - the reaction between an antigen and its antibody - in real time. Using a combination of an immunoassay and surface plasmon resonance imaging (SPR) the device provides a diagnosis in approximately 10 minutes, compared with an hour or more using traditional methods.
Zare believes that, with some further improvements, this combination of immunoassays and SPR in microfluidic devices will have many future applications to real-world problems. 'The results are quite encouraging - so much so that we feel that the prospects for the use of this type of device are quite promising.'
Link to journal article
Microfluidic device for immunoassays based on surface plasmon resonance imaging
Yiqi Luo, Fang Yu and Richard N. Zare, Lab Chip, 2008, 8, 694
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