Issue 9, 1990
From the journal:

Analyst

Adsorptive stripping voltammetric determination of pipemidic acid in human urine

Martin Telting-Diaz,   Arturo J. Miranda Ordieres,   Agustin Costa Garcia,   Paulino Tuñón Blanco,   Dermot Diamond  and  Malcolm R. Smyth  

Abstract

The electrochemical behaviour of pipemidic acid {8-ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)- pyrido[2,3-d]pyrimidine-6-carboxylic acid}, a well known antimicrobial agent used for urinary infections, was investigated by linear-sweep, differential-pulse and square-wave voltammetry at a hanging mercury drop electrode. Two reduction processes were observed in Britton-Robinson buffers at acid pH, whereas only one or two processes were observed in alkaline solutions, dependent on the pH of the buffer employed. Adsorptive effects were used to accumulate the drug on to the electrode. The adsorbed species were measured voltammetrically by using a cathodic process appearing at –0.76 V in 0.1 M HClO4. Linear calibratioin graphs were obtained in the range 2.5 × 10–7M. A simple procedure of extraction was employed for the determination of the drug in urine samples.

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Article information

DOI
https://doi.org/10.1039/AN9901501215
Article type
Paper

Analyst, 1990,115, 1215-1217

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Adsorptive stripping voltammetric determination of pipemidic acid in human urine

M. Telting-Diaz, A. J. M. Ordieres, A. C. Garcia, P. T. Blanco, D. Diamond and M. R. Smyth, Analyst, 1990, 115, 1215 DOI: 10.1039/AN9901501215

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