Journal of the Chemical Society, Chemical Communications
Journal of the Chemical Society, Chemical Communications was published between 1972 - 1995.
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J. Chem. Soc., Chem. Commun., 1995, 2475 - 2476, DOI: 10.1039/C39950002475
Synthesis of enantiomerically pure
-hydroxyaldehydes from the corresponding -hydroxycarboxylic acids: novel substrates for Escherichia coli transketolaseAndrew J. Humphrey, Nicholas J. Turner, Raymond McCague and Stephen J. C. Taylor
Enantiomerically pure (R)-
-hydroxyaldehydes (>95% ee) are prepared from the corresponding -hydroxyesters by silyl protection, reduction with diisobutylaluminium hydride, and finally deprotection under acidic conditions; subsequent coupling of these aldehydes with lithium hydroxypyruvate, catalysed by Escherichia coli transketolase, leads to novel optically pure triols.
