Chemical biology news and research from across RSC Publishing.
Contents list for Highlights in Chemical Biology: Research Articles, issue 8, 2007
Review
Bioinorganic chemistry
J. McMaster,
Annu. Rep. Prog. Chem., Sect. A: Inorg. Chem.
, 2007, 103, 492
DOI: 10.1039/b612874m
Critical Reviews
Electrochemical strategies for the label-free detection of amino acids, peptides and proteins
Grégoire Herzog and Damien W. M. Arrigan,
Analyst, 2007, 132, 615
DOI: 10.1039/b701472d
Speciation and toxicological relevance of manganese in humans
Bernhard Michalke, Stefan Halbach and Volker Nischwitz,
J. Environ. Monit., 2007, 9, 650
DOI: 10.1039/b704173j
Education
An introduction to electrochemical DNA biosensors
Katherine J. Odenthal and J. Justin Gooding,
Analyst, 2007, 132, 603
DOI: 10.1039/b701816a
Enhanced HTML article available
Emerging Area
Nanoparticles and cells: good companions and doomed partnerships
Dusica Maysinger,
Org. Biomol. Chem., 2007, 5, 2335
DOI: 10.1039/b704275b
Feature Article
Interactions of biomolecules with inorganic materials: principles, applications and future prospects
Siddharth V. Patwardhan, Geetanjali Patwardhan and Carole C. Perry,
J. Mater. Chem., 2007, 17, 2875
DOI: 10.1039/b704075j Enhanced HTML article available
Highlights
Reverse interactomics: decoding protein–protein interactions with combinatorial peptide libraries
Dehua Pei and Anne-Sophie Wavreille,
Mol. BioSyst., 2007, 3, 536
DOI: 10.1039/b706041f Enhanced HTML article available
Fingerprinting a killer: surveillance of the influenza virus by mass spectrometry
Kevin M. Downard and Bethny Morrissey,
Analyst, 2007, 132, 611
DOI: 10.1039/b701835e Enhanced HTML article available
Transgenic approaches to study wing color pattern development in Lepidoptera
Diane M. Ramos and Antónia Monteiro,
Mol. BioSyst., 2007, 3, 530
DOI: 10.1039/b701965n Enhanced HTML article available
Dynamic proteomics in mammalian cells: capabilities and challenges
Ron Milo,
Mol. BioSyst., 2007, 3, 542
DOI: 10.1039/b703639f Enhanced HTML article available
Hot off the Press Article
Hot off the press
Hot off the RSC press
Mol. BioSyst., 2007, 3, 516
DOI: 10.1039/b709799a
Method
A novel SNP detection technique utilizing a multiple primer extension (MPEX) on a phospholipid polymer-coated surface
Kazuhide Imai, Yasukazu Ogai, Daisuke Nishizawa, Shinya Kasai, Kazutaka Ikeda and Hisashi Koga,
Mol. BioSyst., 2007, 3, 547
DOI: 10.1039/b701645j Enhanced HTML article available
Opinions
Deduction of intracellular sub-systems from a topological description of the network
Torbjörn E. M. Nordling, Noriko Hiroi, Akira Funahashi and Hiroaki Kitano,
Mol. BioSyst., 2007, 3, 523
DOI: 10.1039/b702142a Enhanced HTML article available
Proteomics data validation: why all must provide data
Lennart Martens and Henning Hermjakob,
Mol. BioSyst., 2007, 3, 518
DOI: 10.1039/b705178f
Perspectives
Supramolecular nanocarriers integrated with dendrimers encapsulating photosensitizers for effective photodynamic therapy and photochemical gene delivery
Nobuhiro Nishiyama, Woo-Dong Jang and Kazunori Kataoka,
New J. Chem., 2007, 31, 1074
DOI: 10.1039/b616050f
Fungal photoreceptors: sensory molecules for fungal development and behaviour
Luis M. Corrochano,
Photochem. Photobiol. Sci., 2007, 6, 725
DOI: 10.1039/b702155k Enhanced HTML article available
Excited states and energy transfer among DNA bases in double helices
Dimitra Markovitsi, Thomas Gustavsson and Francis Talbot,
Photochem. Photobiol. Sci., 2007, 6, 717
DOI: 10.1039/b705674e Enhanced HTML article available
Metal sensor proteins: nature's metalloregulated allosteric switches
David P. Giedroc and Alphonse I. Arunkumar,
Dalton Trans., 2007, 3107
DOI: 10.1039/b706769k
Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) in elemental imaging of biological tissues and in proteomics
J. Sabine Becker, Miroslav Zoriy, J. Susanne Becker, Justina Dobrowolska and Andreas Matusch,
J. Anal. At. Spectrom., 2007, 22, 736
DOI: 10.1039/b701558e Enhanced HTML article available
Dendritic vectors for gene transfection
Marine Guillot-Nieckowski, Sara Eisler and François Diederich,
New J. Chem., 2007, 31, 1111
DOI: 10.1039/b614877h Enhanced HTML article available
Technical Notes
Integration of functional myotubes with a Bio-MEMS device for non-invasive interrogation
Kerry Wilson, Peter Molnar and James Hickman,
Lab Chip, 2007, 7, 920
DOI: 10.1039/b617939h
Electric field isolator (EFI) for isolated and electrophoretic manipulation of charged biomolecules
Jae Young Yun, Sang Jun Mun, Seung S. Lee and Hong Gil Nam,
Lab Chip, 2007, 7, 916
DOI: 10.1039/b618099j
Tutorial Reviews
Hair—the most sophisticated biological composite material
Crisan Popescu and Hartwig Höcker,
Chem. Soc. Rev., 2007, 36, 1282
DOI: 10.1039/b604537p
Deep non-invasive Raman spectroscopy of living tissue and powders
Pavel Matousek,
Chem. Soc. Rev., 2007, 36, 1292
DOI: 10.1039/b614777c
Communications
Covalent labelling of fusion proteins in live cells via an engineered receptor–ligand pair
Casey J. Krusemark and Peter J. Belshaw,
Org. Biomol. Chem., 2007, 5, 2201
DOI: 10.1039/b705185a
A cryptic PKS–NRPS gene locus in the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of an antimitotic rhizoxin complex
Nicole Brendel, Laila P. Partida-Martinez, Kirstin Scherlach and Christian Hertweck,
Org. Biomol. Chem., 2007, 5, 2211
DOI: 10.1039/b707762a Enhanced HTML article available
A conjugated polyelectrolyte-based fluorescence sensor for pyrophosphate
Xiaoyong Zhao, Yan Liu and Kirk S. Schanze,
Chem. Commun., 2007, 2914
DOI: 10.1039/b706629e Enhanced HTML article available
Reversible photopadlocking on double-stranded DNA
Kenzo Fujimoto, Shigeo Matsuda, Yoshinaga Yoshimura, Takehiro Ami and Isao Saito,
Chem. Commun., 2007, 2968
DOI: 10.1039/b707524c Enhanced HTML article available
Rhenium fac tricarbonyl bisimine complexes: biologically useful fluorochromes for cell imaging applications
Angelo J. Amoroso, Michael P. Coogan, Jennifer E. Dunne, Vanesa Fernández-Moreira, Jacob B. Hess, Anthony J. Hayes, David Lloyd, Coralie Millet, Simon J. A. Pope and Craig Williams,
Chem. Commun., 2007, 3066
DOI: 10.1039/b706657k Enhanced HTML article available
Probing the stable G-quadruplex transition using quencher-free end-stacking ethynyl pyrene–adenosine
Young Jun Seo, Il Joon Lee, Jeong Wu Yi and Byeang Hyean Kim,
Chem. Commun., 2007, 2817
DOI: 10.1039/b707278c Enhanced HTML article available
An improved phage display methodology for inorganic nanoparticle fabrication
Alan R. Bassindale, Antonio Codina-Barrios, Nunzianda Frascione and Peter G. Taylor,
Chem. Commun., 2007, 2956
DOI: 10.1039/b702650a Enhanced HTML article available
A novel class of metal-directed supramolecular DNA-delivery systems
Itzia Cruz-Campa, Alejandro Arzola, Lynn Santiago, Jason G. Parsons, Armando Varela-Ramirez, Renato J. Aguilera and Juan C. Noveron,
Chem. Commun., 2007, 2944
DOI: 10.1039/b703201c
Rescue of the streptomycin antibiotic activity by using streptidine as a 
decoy acceptor
for the aminoglycoside-inactivating enzyme adenyl transferase
Montserrat Latorre, Pablo Peńalver, Julia Revuelta, Juan Luis Asensio, Eduardo García-Junceda and Agatha Bastida,
Chem. Commun., 2007, 2829
DOI: 10.1039/b704785a Enhanced HTML article available
Highly sensitive detection of dye-labelled DNA using nanostructured gold surfaces
Robert J. Stokes, Alexandra Macaskill, Jennifer A. Dougan, Philip G. Hargreaves, Helen M. Stanford, W. Ewen Smith, Karen Faulds and Duncan Graham,
Chem. Commun., 2007, 2811
DOI: 10.1039/b705873j
Bend-ribbon forming 
-peptides
Abhishek Kothari, M. Khurram N. Qureshi, Elizabeth M. Beck and Martin D. Smith,
Chem. Commun., 2007, 2814
DOI: 10.1039/b706528k Enhanced HTML article available
One-pot synthetic route to polymer–silica assembled capsule encased with nonionic drug molecule
You-Hwan Son, Man park, Young Bin Choy, Hye Ryung Choi, Dong Seok Kim, Kyoung Chan Park and Jin-Ho Choy,
Chem. Commun., 2007, 2799
DOI: 10.1039/b702288c Enhanced HTML article available
Tricarbonylmanganese(I)–lysozyme complex: a structurally characterized organometallic protein
Mathieu Razavet, Vincent Artero, Christine Cavazza, Yohan Oudart, Colette Lebrun, Juan Carlos Fontecilla-Camps and Marc Fontecave,
Chem. Commun., 2007, 2805
DOI: 10.1039/b703887a Enhanced HTML article available
A photoimmobilisation strategy that maximises exploration of chemical space in small molecule affinity selection and target discovery
Suzanne J. Dilly, Matthew J. Bell, Andrew J. Clark, Andrew Marsh, Richard M. Napier, Martin J. Sergeant, Andrew J. Thompson and Paul C. Taylor,
Chem. Commun., 2007, 2808
DOI: 10.1039/b704271j Enhanced HTML article available
Chloride anion transport and copper-mediated DNA cleavage by C-ring functionalized prodigiosenes
Rosa I. Sáez Díaz, Jasmine Regourd, Paul V. Santacroce, Jeffery T. Davis, David L. Jakeman and Alison Thompson,
Chem. Commun., 2007, 2701
DOI: 10.1039/b701919j Enhanced HTML article available
Consecutive GC base pairs determine the energy barrier of DNA duplex formation under molecularly crowded conditions
Xiao-Bo Gu, Shu-ichi Nakano and Naoki Sugimoto,
Chem. Commun., 2007, 2750
DOI: 10.1039/b702865b
The relationships between oxidase and synthase activities of flavin dependent thymidylate synthase (FDTS)
Anatoly Chernyshev, Todd Fleischmann, Eric M. Koehn, Scott A. Lesley and Amnon Kohen,
Chem. Commun., 2007, 2861
DOI: 10.1039/b700977a Enhanced HTML article available
DMT-MM mediated functionalisation of the non-reducing end of glycosaminoglycans
Emiliano Gemma, Alison N. Hulme, Astrid Jahnke, Lan Jin, Malcolm Lyon, Ralf M. Müller and Du
an Uhrín,
Chem. Commun., 2007, 2686
DOI: 10.1039/b617038b
Reversible folding–unfolding, aggregation protection, and multi-year stabilization, in high concentration protein solutions, using ionic liquids
Nolene Byrne, Li-Min Wang, Jean-Philippe Belieres and C. Austen Angell,
Chem. Commun., 2007, 2714
DOI: 10.1039/b618943a Enhanced HTML article available
New fluorescent probes for carbonic anhydrases
Jayati Banerjee, Manas K. Haldar, Sumathra Manokaran, Sanku Mallik and D. K. Srivastava,
Chem. Commun., 2007, 2723
DOI: 10.1039/b701421j Enhanced HTML article available
Papers
Necrosis predominates in the cell death of human colon adenocarcinoma HT-29 cells treated under variable conditions of photodynamic therapy with hypericin
Jaromír Mike, Ján Kleban, Veronika Sa
ková, Viktor Horváth, Erika Jamborová, Alena Vaculová, Alois Kozubík, Ji
ina Hofmanová and Peter Fedoroko,
Photochem. Photobiol. Sci., 2007, 6, 758
DOI: 10.1039/b700350a Enhanced HTML article available
A hierarchical approach for predicting the transport properties of the gramicidin A channel
Zheng Wang and Joel R. Fried,
Soft Matter, 2007, 3, 1041
DOI: 10.1039/b700125h
LNA (locked nucleic acid) and analogs as triplex-forming oligonucleotides
Torben Hřjland, Surender Kumar, B. Ravindra Babu, Tadashi Umemoto, Nanna Albćk, Pawan K. Sharma, Poul Nielsen and Jesper Wengel,
Org. Biomol. Chem., 2007, 5, 2375
DOI: 10.1039/b706101c
Chlorophyll derivatives as visual pigments for super vision in the red
Ilyas Washington, Jilin Zhou, Steffen Jockusch, Nicholas J. Turro, Koji Nakanishi and Janet R. Sparrow,
Photochem. Photobiol. Sci., 2007, 6, 775
DOI: 10.1039/b618104j Enhanced HTML article available
The optical effect of a semiconductor laser on protecting wheat from UV-B radiation damage
Zong-Bo Qiu, Xin-Jun Zhu, Fang-Min Li, Xiao Liu and Ming Yue,
Photochem. Photobiol. Sci., 2007, 6, 788
DOI: 10.1039/b618131g Enhanced HTML article available
Complex formation between cationic 
-1,3-glucan and hetero-sequence oligodeoxynucleotide and its delivery into macrophage-like cells to induce cytokine secretion
Masato Ikeda, Jusaku Minari, Naohiko Shimada, Munenori Numata, Kazuo Sakurai and Seiji Shinkai,
Org. Biomol. Chem., 2007, 5, 2219
DOI: 10.1039/b705997c
Click multivalent neoglycoconjugates as synthetic activators in cell adhesion and stimulation of monocyte/machrophage cell lines
Mariano Ortega-Muńoz, Julia Morales-Sanfrutos, Francisco Perez-Balderas, Fernando Hernandez-Mateo, Ma Dolores Giron-Gonzalez, Natalia Sevillano-Tripero, Rafael Salto-Gonzalez and Francisco Santoyo-Gonzalez,
Org. Biomol. Chem., 2007, 5, 2291
DOI: 10.1039/b706331h Enhanced HTML article available
Evaluation of chemical labeling strategies for monitoring HCV RNA using vibrational microscopy
Matthew Noestheden, Qingyan Hu, Angela M. Tonary, Li-Lin Tay and John Paul Pezacki,
Org. Biomol. Chem., 2007, 5, 2380
DOI: 10.1039/b704812b Enhanced HTML article available
Novel pyrimidine-based amphiphilic molecules: synthesis, spectroscopic properties and applications in two-photon fluorescence microscopic imaging
Bo Liu, Hai-Li Zhang, Jun Liu, Yuan-Di Zhao, Qing-Ming Luo and Zhen-Li Huang,
J. Mater. Chem., 2007, 17, 2921
DOI: 10.1039/b702004j Enhanced HTML article available
Multilayer PDMS microfluidic chamber for controlling brain slice microenvironment
A. J. Blake, T. M. Pearce, N. S. Rao, S. M. Johnson and J. C. Williams,
Lab Chip, 2007, 7, 842
DOI: 10.1039/b704754a
Identification of Conus amadis disulfide isomerase: minimum sequence length of peptide fragments necessary for protein annotation
Konkallu Hanumae Gowd, K. S. Krishnan and Padmanabhan Balaram,
Mol. BioSyst., 2007, 3, 554
DOI: 10.1039/b705382g Enhanced HTML article available
Effects of different head groups and functionalised side chains on the cytotoxicity of ionic liquids
Stefan Stolte, Jürgen Arning, Ulrike Bottin-Weber, Anja Müller, William-Robert Pitner, Urs Welz-Biermann, Bernd Jastorff and Johannes Ranke,
Green Chem., 2007, 9, 760
DOI: 10.1039/b615326g
Studies of structure and phosphorylation of tau protein using high resolution mass spectrometry
J. Susanne Becker and Michael Przybylski,
J. Anal. At. Spectrom., 2007, 22, 761
DOI: 10.1039/b701440f Enhanced HTML article available
Antibody conjugated magnetic PLGA nanoparticles for diagnosis and treatment of breast cancer
Jaemoon Yang, Choong-Hwan Lee, Joseph Park, Sungbaek Seo, Eun-Kyung Lim, Yong Jin Song, Jin-Suck Suh, Ho-Geun Yoon, Yong-Min Huh and Seungjoo Haam,
J. Mater. Chem., 2007, 17, 2695
DOI: 10.1039/b702538f
Rhenium and technetium tricarbonyl complexes anchored by pyrazole-based tripods: novel lead structures for the design of myocardial imaging agents
Leonor Maria, Susana Cunha, Margarida Videira, Lurdes Gano, António Paulo, Isabel C. Santos and Isabel Santos,
Dalton Trans., 2007, 3010
DOI: 10.1039/b705226j
Multi-component assessment of worker exposures in a copper refinery
Part 2. Biological exposure indices for copper, nickel and cobalt
Evert Nieboer, Yngvar Thomassen, Natalya Romanova, Alexander Nikonov, Jon Řyvind Odland and Valery Chaschin,
J. Environ. Monit., 2007, 9, 695
DOI: 10.1039/b618400f
