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Paper

Chem. Commun., 1998, 2531 - 2532, DOI: 10.1039/a805957h

Redox-active metal complexes for imaging hypoxic tissues: structure–activity relationships in copper(II) bis(thiosemicarbazone) complexes

Jason L. J. Dearling and Philip J. Blower

Reduction potential and lipophilicity of the copper(II) bis(thiosemicarbazone) complexes can be independently controlled by alkylation in the diketone backbone and the N-termini of the ligand, allowing optimisation of radiopharmaceuticals strongly selective for hypoxic tissues.