Issue 8, 2003
From the journal:

Chemical Communications

A new dark quencher for use in genetic analysis

Jonathan P. May,a   Lynda J. Brown,b   Ivo Rudloffb  and  Tom Brown*a  

* Corresponding authors

a Department of Chemistry, University of Southampton, Highfield, Southampton, UK
E-mail: tb2@soton.ac.uk
Fax: +44 (0)23 80592991
Tel: +44 (0)23 80592974

b Oswel Research Products Ltd, Biological Sciences Building, University of Southampton, Bassett Cresent East, Southampton, UK
Tel: +44 (0)23 80592984

Abstract

A novel, long-wavelength, non-fluorescent quencher (LQ), based on 1,4-diaminoanthraquinone, has been incorporated at the 3′ and 5′-termini of oligonucleotides. The quencher has been used in Molecular beacons, efficiently quenching the long wavelength fluorophore, Cy5.

Graphical abstract: A new dark quencher for use in genetic analysis

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Article information

DOI
https://doi.org/10.1039/B300934C
Article type
Communication
Submitted
23 Jan 2003
Accepted
06 Mar 2003
First published
18 Mar 2003

Chem. Commun., 2003, 970-971

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A new dark quencher for use in genetic analysis

J. P. May, L. J. Brown, I. Rudloff and T. Brown, Chem. Commun., 2003, 970 DOI: 10.1039/B300934C

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