Issue 20, 2003
From the journal:

Chemical Communications

Lewis acid mediated cyclisations of silylated methylenecyclopropyl hydrazones

Lee Patient,a   Malcolm B. Berry,b   Simon J. Coles,a   Mike B. Hursthousea  and  Jeremy D. Kilburn*a  

* Corresponding authors

a Department of Chemistry, University of Southampton, Southampton, UK
E-mail: jdk1@soton.ac.uk
Fax: 023 80596805
Tel: 023 80593596

b GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts, UK

Abstract

Silylated methylenecyclopropyl hydrazones on treatment with BF3·Et2O cyclise to give heterocyclic products involving a novel sequence of hydride and silyl shifts via a series of increasingly stable cationic intermediates.

Graphical abstract: Lewis acid mediated cyclisations of silylated methylenecyclopropyl hydrazones

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Article information

DOI
https://doi.org/10.1039/B306636C
Article type
Communication
Submitted
11 Jun 2003
Accepted
29 Aug 2003
First published
17 Sep 2003

Chem. Commun., 2003, 2552-2553

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Lewis acid mediated cyclisations of silylated methylenecyclopropyl hydrazones

L. Patient, M. B. Berry, S. J. Coles, M. B. Hursthouse and J. D. Kilburn, Chem. Commun., 2003, 2552 DOI: 10.1039/B306636C

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