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Chem. Commun., 2003, 2843 - 2846, DOI: 10.1039/b311008g
Enzymatic hydrogen atom abstraction from polyunsaturated fatty acids
Chris M. McGinley and Wilfred A. van der Donk
The oxidation of polyunsaturated fatty acids such as arachidonic and linoleic acid initiates a plethora of cell signaling pathways in animals and plants. The chemistry of the enzymatic oxidation has been investigated for several enzymes, most notably prostaglandin synthase and the lipoxygenases, revealing many surprises and impressive examples of enzymatic control of hydrogen atom abstraction and subsequent oxygenation.
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