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Chem. Commun., 2004, 890 - 891, DOI: 10.1039/b400978a

Solvent-drop grinding: green polymorph control of cocrystallisation

Andrew V. Trask, W. D. Samuel Motherwell and William Jones

By grinding with a minimal addition of a solvent of appropriate polarity, control over the polymorphic outcome of a novel cocrystallisation involving the model pharmaceutical compound caffeine may be achieved.

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