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Chem. Commun., 2005, 1261 - 1263, DOI: 10.1039/b412670j

Supramolecular assemblies of DNA with neutral nucleoside amphiphiles

Philippe Barthelemy, Carla A. H. Prata, Shaun F. Filocamo, Chad E. Immoos, Benjamin W. Maynor, S. A. Nadeem Hashmi, Stephen J. Lee and Mark W. Grinstaff

A neutral uridine-based amphiphile is described which condenses plasmid DNA. AFM studies show that the three distinct structural components of the amphiphile (i.e, nucleobase, alkyl chains, and poly(ethylene glycol)) are required for the formation of DNA–amphiphile supramolecular assemblies on a mica surface.

Graphical abstract image for this article (ID: b412670j)