Issue 40, 2005
From the journal:

Chemical Communications

Total synthesis of a diastereomer of the marine natural product clavosolide A

Conor S Barry,a   Nick Bushby,b   Jonathan P. H. Charmant,a   Jon D. Elsworth,a   John R. Hardingb  and  Christine L. Willis*a  

* Corresponding authors

a School of Chemistry, University of Bristol, Cantock's Close, Bristol, UK
E-mail: chris.willis@bristol.ac.uk

b AstraZeneca UK Ltd., Mereside, Alderley Park, Macclesfield, UK

Abstract

The first total synthesis of the reported structure of the sponge metabolite clavosolide A is described using a Prins cyclisation to assemble the tetrahydropyran core followed by manipulation of the side-chain, dimerisation and finally glycosidation.

Graphical abstract: Total synthesis of a diastereomer of the marine natural product clavosolide A

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Article information

DOI
https://doi.org/10.1039/B509757F
Article type
Communication
Submitted
11 Jul 2005
Accepted
08 Aug 2005
First published
15 Sep 2005

Chem. Commun., 2005, 5097-5099

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Total synthesis of a diastereomer of the marine natural product clavosolide A

C. S. Barry, N. Bushby, J. P. H. Charmant, J. D. Elsworth, J. R. Harding and C. L. Willis, Chem. Commun., 2005, 5097 DOI: 10.1039/B509757F

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