Issue 13, 2006
From the journal:

Chemical Communications

Iron nanoparticles in the coupling of alkyl halides with aryl Grignard reagents†

Robin B. Bedford,*a   Michael Betham,a   Duncan W. Bruce,b   Sean A. Davis,a   Robert M. Frostc  and  Michael Hirdd  

* Corresponding authors

a School of Chemistry, University of Bristol, Cantock's Close, Bristol, UK
E-mail: r.bedford@bristol.ac.uk

b Department of Chemistry, University of York, Heslington, York, UK

c Department of Chemistry, University of Exeter, Exeter, UK

d Kingston Chemicals, University of Hull, Cottingham Road, Kingston upon Hull, UK

Abstract

Iron nanoparticles, either formed in situ stabilized by 1,6-bis(diphenylphosphino)hexane or polyethylene glycol (PEG), or preformed stabilized by PEG, are excellent catalysts for the cross-coupling of aryl Grignard reagents with primary and secondary alkyl halides bearing β-hydrogens and they also prove effective in a tandem cyclization/cross-coupling reaction.

Graphical abstract: Iron nanoparticles in the coupling of alkyl halides with aryl Grignard reagents

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Article information

DOI
https://doi.org/10.1039/B601014H
Article type
Communication
Submitted
20 Jan 2006
Accepted
17 Feb 2006
First published
03 Mar 2006

Chem. Commun., 2006, 1398-1400

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Iron nanoparticles in the coupling of alkyl halides with aryl Grignard reagents

R. B. Bedford, M. Betham, D. W. Bruce, S. A. Davis, R. M. Frost and M. Hird, Chem. Commun., 2006, 1398 DOI: 10.1039/B601014H

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