Issue 40, 2006

Synthesis of the DEF-bis-spiroacetal of spirastrellolide A exploiting a double asymmetric dihydroxylation/spiroacetalisation strategy

Abstract

An efficient synthesis of the C26–C40 tricyclic [5,6,6]-bis-spiroacetal segment of the marine macrolide spirastrellolide A has been developed, exploiting a novel double Sharpless asymmetric dihydroxylation/spiroacetalisation sequence.

Graphical abstract: Synthesis of the DEF-bis-spiroacetal of spirastrellolide A exploiting a double asymmetric dihydroxylation/spiroacetalisation strategy

Supplementary files

Article information

Article type
Communication
Submitted
04 Sep 2006
Accepted
06 Sep 2006
First published
20 Sep 2006

Chem. Commun., 2006, 4186-4188

Synthesis of the DEF-bis-spiroacetal of spirastrellolide A exploiting a double asymmetric dihydroxylation/spiroacetalisation strategy

I. Paterson, E. A. Anderson, S. M. Dalby, J. H. Lim, P. Maltas and C. Moessner, Chem. Commun., 2006, 4186 DOI: 10.1039/B612697A

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