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Chem. Commun., 2007, 1896 - 1898, DOI: 10.1039/b702768k

Adenosine residues in the template do not block spontaneous replication steps of RNA

Stephanie R. Vogel and Clemens Richert

Sub-freezing temperatures, azabenzotriazolide activation, multiple monomer addition, and helper displacement help to overcome what seemed like an intrinsic block of adenine-templated RNA replication steps in the absence of enzymes.

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