Issue 17, 2007
From the journal:

Chemical Communications

Catalytic asymmetric hydrogenation of aldehydes

Xiaoguang Lia  and  Benjamin List*a  

* Corresponding authors

a Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany
E-mail: list@mpi-muelheim.mpg.de
Fax: (+208) 306 2999

Abstract

Racemic α-arylaldehydes provide the corresponding primary alcoholsvia dynamic kinetic resolution in excellent enantioselectivities and yields upon hydrogenation using a Noyori ruthenium catalyst; for example, the biologically active (S)-enantiomer of the non-steroidal anti-inflammatory drug ibuprofen could be synthesized via catalytic enantioselective hydrogenation of aldehyde1f followed by oxidation with potassium permanganate in 76% isolated yield and 96 : 4 er.

Graphical abstract: Catalytic asymmetric hydrogenation of aldehydes

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Article information

DOI
https://doi.org/10.1039/B703977H
Article type
Communication
Submitted
15 Mar 2007
Accepted
27 Mar 2007
First published
05 Apr 2007

Chem. Commun., 2007, 1739-1741

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Catalytic asymmetric hydrogenation of aldehydes

X. Li and B. List, Chem. Commun., 2007, 1739 DOI: 10.1039/B703977H

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