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Chem. Commun., 2007, 4143 - 4145, DOI: 10.1039/b706793c

Highly diastereoselective and enantioselective direct organocatalytic anti-selective Mannich reactions employing N-tosylimines

Lili Cheng, Xiao Han, Huiming Huang, Ming Wah Wong and Yixin Lu

Organocatalytic direct anti-selective Mannich reactions of O-TBS-hydroxyacetone with various N-tosylimines derived from aromatic aldehydes in the presence of L-threonine-derived catalyst afforded 1,2-amino alcohols in good yields and with enantioselectivities of 99% in almost all cases.

Graphical abstract image for this article (ID: b706793c)