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Chem. Commun., 2007, 4366 - 4368, DOI: 10.1039/b709898g

Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum–phenanthroline complex

Julie E. Reed, Stephen Neidle and Ramon Vilar

Two new mono-substituted phenanthroline ligands and their platinum(II) square planar complexes have been prepared; one of the complexes has been shown to induce a high degree of quadruplex DNA stabilisation and to inhibit telomerase.

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