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Feature Article

Chem. Commun., 2008, 413 - 424, DOI: 10.1039/b710355g

Molecular recognition in homogeneous transition metal catalysis: a biomimetic strategy for high selectivity

Siddartha Das, Gary W. Brudvig and Robert H. Crabtree

Traditional methods for selectivity control in homogeneous transition metal catalysis either employ steric effects in a binding pocket or chelate control. In a supramolecular strategy, encapsulation of the substrate can provide useful shape and size selectivity. A fully developed molecular recognition strategy involving hydrogen bonding or solvophobic forces has given almost completely regioselective functionalization of remote, unactivated C–H bonds.

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