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Chemical Communications

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Chem. Commun., 2007, 3640 - 3642, DOI: 10.1039/b710456a


A template-based mnemonic for monoamine oxidase (MAO-N) catalyzed reactions and its application to the chemo-enzymatic deracemisation of the alkaloid (±)-crispine A

Kevin R. Bailey, Andrew J. Ellis, Renate Reiss, Timothy J. Snape and Nicholas J. Turner


A template-based mnemonic has been developed for the enzyme monoamine oxidase from Aspergillus niger and has been used to successfully identify the alkaloid (±)-crispine A as a target for chemo-enzymatic deracemisation yielding the biologically active (R)-enantiomer in 97% e.e.

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