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Communication

Chem. Commun., 2008, 3525 - 3527, DOI: 10.1039/b808305c

Toward the discovery of potent inhibitors of botulinum neurotoxin A: development of a robust LC MS based assay operational from low to subnanomolar enzyme concentrations

Kateina apková, Mark S. Hixon, Laura A. McAllister and Kim D. Janda

The development of a sensitive, yet reliable assay for the analysis of botulinum neurotoxin A (BoNT/A) inhibitors is described; using this assay a new protease inhibitor was characterized and found to be one of the most potent inhibitors reported to date.

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