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Communication

Chem. Commun., 2008, 5128 - 5130, DOI: 10.1039/b811159f


Design of a novel molecular beacon: modification of the stem with artificially genetic alphabet

Pinpin Sheng, Zunyi Yang, Youngmi Kim, Yanrong Wu, Weihong Tan and Steven A. Benner


A molecular beacon that incorporates components of an artificially expanded genetic information system (AEGIS) in its stem is shown not to be opened by unwanted stem invasion by adventitious standard DNA; this should improve the darkness of the beacon in real-world applications.

Graphical abstract image for this article  (ID: b811159f)