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Communication
Chem. Commun., 2008, 5295 - 5297, DOI: 10.1039/b814576h
Click chemistry assembly of G-quadruplex ligands incorporating a diarylurea scaffold and triazole linkers
William C. Drewe and Stephen Neidle
A series of diarylurea ligands were designed to interact selectively with G-quadruplexes and were synthesised using copper(I) catalysed
click
chemistry to incorporate the 1,4-substituted 1,2,3-triazole ring into the core of the ligands; the optimal ligands demonstrate a high degree of selective telomeric G-quadruplex stabilisation and are not cytotoxic in several cancer cell lines.
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