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Communication
Chem. Commun., 2008, 6570 - 6572, DOI: 10.1039/b815918a
Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery
Ahn Na Koo, Hong Jae Lee, Sung Eun Kim, Jeong Ho Chang, Chiyoung Park, Chulhee Kim, Jae Hyung Park and Sang Cheon Lee
We report biocompatible, cell-permeable core–shell–corona polymer micelles bearing glutathione-cleavable shell cross-links, which allow the facilitated release of entrapped anticancer drugs at cytoplasm in response to an intracellular glutathione level.
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