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Chem. Commun., 2009, 7033 - 7035, DOI: 10.1039/b909666c

Biological screening of a diverse set of AI-2 analogues in Vibrio harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous

Jacqueline A. I. Smith, Jingxin Wang, Sao-Mai Nguyen-Mau, Vincent Lee and Herman O. Sintim

C1-alkyl AI-2 analogues do not induce bioluminescence in V. harveyi on their own but enhance the bioluminescence induced by AI-2 in a synergistic fashion. A new facile synthesis of AI-2 facilitates the synthesis of a diverse set of AI-2 analogues and biological screening suggests that receptors that are involved in the synergistic bioluminescence production in V. harveyi are promiscuous.

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