Issue 17, 2010

The first F-ring modified ciguatoxin analogue showing significant toxicity

Abstract

Ciguatoxins, the principal causative toxins of ciguatera seafood poisoning, are potent neurotoxic polycyclic ethers. We report herein the total synthesis of a 10-membered F-ring analogue of 51-hydroxyCTX3C, which constitutes the first example of an F-ring modified ciguatoxin that exhibits potent cytotoxicity as well as mouse acute toxicity.

Graphical abstract: The first F-ring modified ciguatoxin analogue showing significant toxicity

Supplementary files

Article information

Article type
Communication
Submitted
20 Nov 2009
Accepted
12 Feb 2010
First published
05 Mar 2010

Chem. Commun., 2010,46, 2968-2970

The first F-ring modified ciguatoxin analogue showing significant toxicity

Y. Ishihara, N. Lee, N. Oshiro, S. Matsuoka, S. Yamashita, M. Inoue and M. Hirama, Chem. Commun., 2010, 46, 2968 DOI: 10.1039/B924375E

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