Issue 16, 2010
From the journal:

Chemical Communications

Organocatalyzed enantioselective one-pot three-component access to indoloquinolizidines by a Michael addition–Pictet–Spengler sequence†

Xiaoyu Wu,*a   Xiaoyang Dai,a   Linlin Nie,a   Huihui Fang,a   Jie Chen,a   Zhongjiao Ren,a   Weiguo Cao*a  and  Gang Zhao*b  

* Corresponding authors

a Department of Chemistry, Shanghai University, 99 Shangda Rd, Shanghai 200444, People's Republic of China
E-mail: wuxy@shu.edu.cn, wgcao@mail.shu.edu.cn
Fax: (+86)-21-6683-4856

b Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, People's Republic of China
E-mail: zhaog@mail.sioc.ac.cn
Fax: (+86)-21-6416-6128

Abstract

The enantioselective three-component Michael addition–Pictet–Spengler sequence of β-ketoesters 1, α,β-unsaturated aldehydes 2 and tryptamines 4 represents a facile and rapid one-pot access to highly substituted indoloquinolizidines in moderate to excellent yields and good to excellent enantioselectivities.

Graphical abstract: Organocatalyzed enantioselective one-pot three-component access to indoloquinolizidines by a Michael addition–Pictet–Spengler sequence

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Article information

DOI
https://doi.org/10.1039/C001512A
Article type
Communication
Submitted
25 Jan 2010
Accepted
25 Feb 2010
First published
19 Mar 2010

Chem. Commun., 2010,46, 2733-2735

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Organocatalyzed enantioselective one-pot three-component access to indoloquinolizidines by a Michael addition–Pictet–Spengler sequence

X. Wu, X. Dai, L. Nie, H. Fang, J. Chen, Z. Ren, W. Cao and G. Zhao, Chem. Commun., 2010, 46, 2733 DOI: 10.1039/C001512A

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