Issue 38, 2010

Selective and sensitive detection and quantification of arylamine N-acetyltransferase 2 by a ratiometric fluorescence probe

Abstract

A novel NAT2 specific probe has been developed for sensitive detection of the activity of NAT2. Upon NAT2 catalyzed acetylation of the molecule to N-acetyl-amonafide, the ratiometric response of fluorescence with significant changes in wavelength and intensity is observed. Its significant application potential has been successfully demonstrated in cellular systems.

Graphical abstract: Selective and sensitive detection and quantification of arylamine N-acetyltransferase 2 by a ratiometric fluorescence probe

Supplementary files

Article information

Article type
Communication
Submitted
18 Apr 2010
Accepted
19 Jul 2010
First published
26 Aug 2010

Chem. Commun., 2010,46, 7121-7123

Selective and sensitive detection and quantification of arylamine N-acetyltransferase 2 by a ratiometric fluorescence probe

L. Cui, Y. Zhong, W. Zhu, Y. Xu and X. Qian, Chem. Commun., 2010, 46, 7121 DOI: 10.1039/C0CC01000F

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