Issue 17, 2003
From the journal:

Physical Chemistry Chemical Physics

Standard partition coefficients of anionic drugs in the n-octanol/water system determined by voltammetry at three-phase electrodes

Géraldine Bouchard,a   Alexandra Galland,a   Pierre-Alain Carrupt,*a   Rubin Gulaboski,b   Valentin Mirčeski,b   Fritz Scholzb  and  Hubert H. Giraultc  

* Corresponding authors

a Institut de Chimie Thérapeutique, Université de Lausanne, CH-1015, Lausanne, Switzerland
E-mail: Pierre-Alain.Carrupt@ict.unil.ch

b Institut für Chemie und Biochemie, E.-M.-Arndt-Universität, Soldtmannstrasse 23, Greifswald, Germany

c Laboratoire d'Électrochimie Physique et Analytique, École Polytechnique Fédérale de Lausanne, CH-1015, Lausanne, Switzerland

Abstract

The anionic forms of 26 drugs and organic model compounds have been extensively explored in the n-octanol/water system using voltammetry at three-phase electrodes. The objective of this study was to validate the ability of this electrochemical system to give reliable values of lipophilicity for organic ions, as well as to gain more information on the lipophilic behaviour of anions in the n-octanol/water system. Results were used to clarify the solvation mechanisms responsible for ion partitioning and to compare the information obtained in the two solvent systems n-octanol/water and 1,2-dichloroethane/water.

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Article information

DOI
https://doi.org/10.1039/B304113A
Article type
Paper
Submitted
14 Apr 2003
Accepted
10 Jul 2003
First published
31 Jul 2003

Phys. Chem. Chem. Phys., 2003,5, 3748-3751

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Standard partition coefficients of anionic drugs in the n-octanol/water system determined by voltammetry at three-phase electrodes

G. Bouchard, A. Galland, P. Carrupt, R. Gulaboski, V. Mirčeski, F. Scholz and H. H. Girault, Phys. Chem. Chem. Phys., 2003, 5, 3748 DOI: 10.1039/B304113A

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