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Dalton Transactions

The international journal for inorganic, organometallic and bioinorganic chemistry



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Dalton Trans., 2007, 4962 - 4973, DOI: 10.1039/b704832g

[(-C5H4R)Fe(CO)2X], X = Cl, Br, I, NO3, CO2Me and [(-C5H4R)Fe(CO)3]+, R = (CH2)nCO2Me (n = 0–2), and CO2CH2CH2OH: a new group of CO-releasing molecules

David Scapens, Harry Adams, Tony R. Johnson, Brian E. Mann, Philip Sawle, Rehan Aqil, Trevor Perrior and Roberto Motterlini

A new group of CO-releasing molecules, CO-RMs, based on cyclopentadienyl iron carbonyls have been identified. X-Ray structures have been determined for [(-C5H4CO2Me)Fe(CO)2X], X = Cl, Br, I, NO3, CO2Me, [(-C5H4CO2Me)Fe(CO)2]2, [(-C5H4CO2CH2CH2OH)Fe(CO)2]2 and [(-C5H4CO2Me)Fe(CO)3][FeCl4]. Half-lives for CO release, 1H, 13C, and 17OC NMR and IR spectra have been determined along with some biological data for these compounds, [(-C5H4CO2CH2CH2OH)Fe(CO)3]+ and [{-C5H4(CH2)nCO2Me}Fe(CO)3]+, n = 1, 2. More specifically, cytotoxicity assays and inhibition of nitrite formation in stimulated RAW264.7 macrophages are reported for most of the compounds analyzed. [(-C5H5)Fe(CO)2X], X = Cl, Br, I, were also examined for comparison. Correlations between the half-lives for CO release and spectroscopic parameters are found within each group of compounds, but not between the groups.

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