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Dalton Transactions

The international journal for inorganic, organometallic and bioinorganic chemistry



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Dalton Trans., 2007, 4974 - 4979, DOI: 10.1039/b706246j

106Ru radiolabelling of the antitumour complex [(6-fluorene)Ru(en)Cl]PF6

James D. Hoeschele, Abraha Habtemariam, Jeanette Muir and Peter J. Sadler

The organometallic half-sandwich RuII arene anticancer complex [(6-fluorene)Ru(en)Cl]PF6 ( 1) has been synthesized in high yield and purity on a micromole scale with incorporation of the -emitting radioisotope 106Ru (half-life = 1.01 y) using a refined procedure involving conversion of RuCl3 into [(6-fluorene)RuCl2]2, and then [(6-fluorene)Ru(CH3CN)2Cl]PF6 as intermediates. Distribution studies 0.25 h post i.v. injection of 106Ru- 1 at a dose of 25 mg 1 kg–1 show that 106Ru is well distributed throughout the tissues of a rat. This appears to be the first report of the radiolabelling of a potential ruthenium antitumour agent for distribution/biological studies.

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