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Dalton Transactions

The international journal for inorganic, organometallic and bioinorganic chemistry



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Dalton Trans., 2007, 4169 - 4174, DOI: 10.1039/b706856e

Kinetics and mechanism of the substitution behaviour of Pd(II) piperazine complexes with different biologically relevant nucleophiles

Azza Shoukry, Malgorzata Brindell and Rudi van Eldik

The interaction of the palladium(II) complex [Pd(Pip)(H2O)2]2+, where Pip is piperazine, with a series of biologically relevant nucleophiles including guanosine-5-monophosphate, L-methionine and thiourea was studied under pseudo-first-order conditions as a function of nucleophile concentration and temperature, using UV-Vis spectrophotometric and stopped-flow techniques. The reactions were found to occur in two subsequent steps. For the sulfur donor containing nucleophiles thiourea and L-methionine, a third reaction step, the displacement of the labilized amine, as a result of the strong trans-effect of S-donor ligands, was observed. The activation parameters for all reactions studied suggest an associative substitution mechanism.

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