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Dalton Transactions

The international journal for inorganic, organometallic and bioinorganic chemistry



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Dalton Trans., 2007, 3983 - 3990, DOI: 10.1039/b707121c

Bioreductive activation and drug chaperoning in cobalt pharmaceuticals

Matthew D. Hall, Timothy W. Failes, Natsuho Yamamoto and Trevor W. Hambley

The potential for cobalt(III) complexes in medicine, as chaperones of bioactive ligands, and to target tumours through bioreductive activation, has been examined over the past 20 years. Despite this, chemical properties such as reduction potential and carrier ligands required for optimal tumour targeting and drug delivery have not been optimised. Here we review the chemistry of cobalt(III) drug design, and recent developments in the understanding of the cellular fate of these drugs.

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