_tcm18-11401.gif )
The international journal for inorganic, organometallic and bioinorganic chemistry
Subscribers
Non-subscribers
- Purchase article PDF [£27 + taxes]
- Purchase article PDF member offer [£5 + taxes]
Free access
Perspective
Dalton Trans., 2007, 4751 - 4759, DOI: 10.1039/b712138e
Why does nature use zinc-a personal view
Heinrich Vahrenkamp
In this perspective some results from the work by the author's research group on the coordination chemistry of zinc are presented. They are selected so as to highlight the principles which, in the opinion of the author, make zinc unique in its ability to function as the catalytic center for an ever-increasing number of biological processes. In essence, the
non-properties
of zinc are the basis of its success: no redox chemistry, no ligand field effects, no typical coordination numbers or geometries, no stability or inertness of its complexes, no typical hard or soft characteristics. The chemistry presented here is centered around the Freiburg Enzyme Model, the pyrazolylborate-ligated zinc-hydroxide complex. The topics discussed in detail include the zinc–water combination, the non-similarity between the Zn–OH and the Zn–SH, Zn–OR or Zn–SR complexes, and the functionalization of CO2 by zinc-bound nucleophiles. The value of structure correlation analysis for the elucidation of mechanistic details is demonstrated, and the first examples of catalysis by the TpZn–OH complexes are presented.
RSS feed