Paper

Dalton Trans., 2008, 4038 - 4043, DOI: 10.1039/b806548a

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Oligopyridine ligands derived from amino acid precursors: Their Zn²⁺ complexation and effects on hepatic stellate cell functions

Hiroshi Tsukube, Yuki Noda, Yumiko Kataoka, Hiroyuki Miyake, Satoshi Shinoda, Akiko Kojima-Yuasa, Yoshitake Nishida and Isao Matsui-Yuasa

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A series of oligopyridine ligands were derived from amino acid amides in which amide oxygen and ternary nitrogen atoms were combined with pyridine moieties. ¹H NMR and circular dichroism spectroscopic characterizations revealed that they formed stable Zn²⁺ complexes in neutral aqueous solutions and caused Zn²⁺ deficiency in the hepatic stellate cell systems. Since collagen synthesis was effectively promoted in the cells, the present oligopyridine derivatives worked as biocompatible ligands for Zn²⁺ complexation and cell activation.

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