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The international journal for inorganic, organometallic and bioinorganic chemistry
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Paper
Dalton Trans., 2008, 6159 - 6164, DOI: 10.1039/b807965j
Bisursodeoxycholate(ethylenediamine)platinum(II): a new autofluorescent compound. Cytotoxic activity and cell cycle analysis in ovarian and hematological cell lines
Martín Pérez-Andrés, Juan J. Benito, Emilio Rodríguez-Fernández, Bruna Corradetti, Daniel Primo, Juan L. Manzano, Alberto Orfao and Julio J. Criado
The present paper describes for the first time an intrinsic fluorescent square-planar platinum(II) complex carrying two ursodeoxycholate ligands ([Pt(UDC)2(en)], where UDC- = ursodeoxycholate), that emits at room temperature once free in solution. Kinetic studies were carried out in aqueous solution and in the presence of different NaCl concentrations: 4 mM (similar to cytoplasmic concentration) and 150 mM (similar to plasmatic concentration). This novel compound was synthesized from a [PtCl2(en)] complex and shows increased cytotoxic activity against both resting and cycling HeLa cells, with no toxicity for cell lines derived from neoplastic haematopoietic cells.
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