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Dalton Transactions

The international journal for inorganic, organometallic and bioinorganic chemistry



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Dalton Trans., 2009, 8399 - 8405, DOI: 10.1039/b911450e

Synthesis of ferrocene tethered open and macrocyclic bis--lactams and bis--amino acid derivatives

Miguel A. Sierra, Mamen Rodríguez-Fernández, Luis Casarrubios, Mar Gómez-Gallego, Charles P. Allen and María José Mancheño

New bioorganometallic ferrocene derivatives are synthesized through a Diversity Oriented Synthesis strategy. Easily available ferrocene bisimines have been transformed into open ferrocenyl bis--lactams. These compounds have demonstrated to be versatile synthons used in further transformations into new ferrocene bis--amino acids. Carefully selected substituents submitted to ring closing metathesis (RCM) and Cu-catalyzed oxidative alkyne coupling conditions have also allowed the conversion of open substrates into ferrocenic macrocyclic bis--lactams.

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