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Article citation: Raymond Wai-Yin Sun, Dalton Trans., 2009, DOI: 10.1039/b912236b

Dual anti-angiogenic and cytotoxic properties of ruthenium(III) complexes containing pyrazolato and/or pyrazole ligands

Raymond Wai-Yin Sun, Miro Fei-Yeung Ng, Ella Lai-Ming Wong, Jingfei Zhang, Stephen Sin-Yin Chui, Lam Shek, Tai-Chu Lau and Chi-Ming Che

An oxo-bridged diruthenium(III) complex containing pyrazolato and pyrazole ligands is stable against ascorbic-acid reduction, induces apoptosis (60%, 48 h) against HeLa cells at 10 M level and exhibits promising anti-angiogenic activity at its sub-cytotoxic concentrations. Other mononuclear ruthenium(III) complexes containing pyrazole ligands [Ru(pz)4X2]+ exhibit dual anti-angiogenic and cytotoxic properties.

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