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Dalton Transactions

The international journal for inorganic, organometallic and bioinorganic chemistry



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Dalton Trans., 2009, 9712 - 9714, DOI: 10.1039/b917566k

A new bifunctional GdIII complex of enhanced efficacy for MR-molecular imaging applications

Lorenzo Tei, Giuseppe Gugliotta, Zsolt Baranyai and Mauro Botta

Increasing the length of the carboxyamide arm of a GdDOTA monoamide (DOTA = 1,4,7,10-tetraaza-1,4,7,10-tetrakis(carboxymethyl)cyclododecane) complex from acetic to propionic accelerates the water exchange rate (kex) by nearly two orders of magnitude; the 1H relaxivity of the corresponding macromolecular derivatives may then be remarkably enhanced in MRI-based molecular imaging applications, as exemplified in the case of micellar systems.

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