Communication

Article citation: Christian R. Kowol, Dalton Trans., 2010, DOI: 10.1039/b919119b

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Fluorescence properties and cellular distribution of the investigational anticancer drug Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) and its zinc(II) complex

Christian R. Kowol, Robert Trondl, Vladimir B. Arion, Michael A. Jakupec, Irene Lichtscheidl and Bernhard K. Keppler

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Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone), which entered several phase I and II clinical trials as an antitumor chemotherapeutic agent, was found to possess intrinsic fluorescence properties (_ex = 360 nm), which enabled us to monitor the uptake and intracellular distribution in living human cancer cells by fluorescence microscopy.

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