Issue 13, 2010
From the journal:

Dalton Transactions

New 7-azaindole palladium and platinum complexes: crystal structures and theoretical calculations. In vitro anticancer activity of the platinum compounds†

José Ruiz,*a   Venancio Rodríguez,a   Concepción de Haro,a   Arturo Espinosa,*b   José Pérezc  and  Christoph Janiakd  

* Corresponding authors

a Departamento de Química Inorgánica, Facultad de Química, Universidad de Murcia, Murcia, Spain
E-mail: jruiz@um.es
Fax: +34 868 384148
Tel: +34 868 887455

b Departamento de Química Orgánica, Facultad de Química, Universidad de Murcia, Murcia, Spain
E-mail: artuesp@um.es
Fax: +34 868884149
Tel: +34 868 887489

c Departamento de Ingeniería Minera, Geológica y Cartográfica (Área de Química Inorgánica), Universidad Politécnica de Cartagena, Cartagena, Spain
E-mail: Jose.Pperez@upct.es
Fax: +34 968 325420
Tel: +34 968 326420

d Institut für Anorganische und Analytische Chemie, Universität Freiburg, Albertstr., 21, Freiburg, Germany
E-mail: janiak@uni-freiburg.de
Fax: +49 761 2036147
Tel: +49 761 2036127

Abstract

A series of new 7-azaindolyl palladium and platinum complexes have been prepared. The X-ray structure determinations of [NBu4][M(C6F5)2(Haza-N7)(aza-N1)]·Haza [M = Pd, Pt; aza = 7-azaindolate (lH-pyrrolo[2,3-b]pyridinate)] have established for the first time the coordination to the same metal centre of both neutral and anionic forms of the ligand. Theoretical calculations at the mPW1B95/aug6-31G**/StRSCecp level show that both kinetic and thermodynamic arguments support the observed coordination and H-bonding interaction of the pyrrolo and pyridine moieties of the neutral and deprotonated heterocyclic ligands. At 48 h incubation time the new platinum complex [Pt(dmba)(aza-N1)(DMSO)] (dmba = N,N-dimethylbenzylamine-κN,κC) shows sub-micromolar activity both in A2780 and T47D [IC50 (μM) = 0.34 and 0.53, respectively]. The DNA adduct formation of the new platinum complexes was followed by circular dichroism and electrophoretic mobility.

Graphical abstract: New 7-azaindole palladium and platinum complexes: crystal structures and theoretical calculations. In vitro anticancer activity of the platinum compounds

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Article information

DOI
https://doi.org/10.1039/B920854B
Article type
Paper
Submitted
07 Oct 2009
Accepted
15 Jan 2010
First published
13 Feb 2010

Dalton Trans., 2010,39, 3290-3301

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New 7-azaindole palladium and platinum complexes: crystal structures and theoretical calculations. In vitro anticancer activity of the platinum compounds

J. Ruiz, V. Rodríguez, C. de Haro, A. Espinosa, J. Pérez and C. Janiak, Dalton Trans., 2010, 39, 3290 DOI: 10.1039/B920854B

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