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Green Chem., 2007, 9, 1185 - 1190, DOI: 10.1039/b700893g

PEG mediated synthesis of amino-functionalised 2,4,6-triarylpyridines

Nicole M. Smith, Colin L. Raston, Christopher B. Smith and Alexandre N. Sobolev

The reaction of p-aminoacetophenone with aryl aldehydes in polyethylene glycol (PEG) in the presence of base, followed by treatment with ammonium acetate, affords 2,4,6-triarylpyridines in good yield as a one pot procedure. The intermediate Claisen–Schmidt chalcone condensation products or the Michael addition 1,5-diketone products can be prepared in high yield, depending on the ratio of ketone to aldehyde, prior to treatment with ammonium acetate.

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