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Paper

Green Chem., 2009, 11, 538 - 542, DOI: 10.1039/b821623a

Long term continuous chemoenzymatic dynamic kinetic resolution of rac-1-phenylethanol using ionic liquids and supercritical carbon dioxide

Pedro Lozano, Teresa De Diego, Corina Mira, Kimberley Montague, Michel Vaultier and José L. Iborra

The long term continuous dynamic kinetic resolution (DKR) of rac-phenylethanol in IL/scCO2 biphasic systems was carried out by simultaneously using immobilized lipase (Novozym 435) and acidic zeolite catalysts at 50 °C and 100 bar, providing good yields (up to 98.0%) for R-phenylethyl propionate with excellent enantioselectivity (up to 97.3% ee) and without any activity loss during 14 days of operation.

Graphical abstract image for this article (ID: b821623a)