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Green Chem., 2009, 11, 492 - 497, DOI: 10.1039/b821842k

Antibiofilm activities of 1-alkyl-3-methylimidazolium chloride ionic liquids

Louise Carson, Peter K. W. Chau, Martyn J. Earle, Manuela A. Gilea, Brendan F. Gilmore, Sean P. Gorman, Maureen T. McCann and Kenneth R. Seddon

Microbial biofilms are ubiquitous in nature and represent the predominant mode of growth of microorganisms. A general characteristic of biofilm communities is that they tend to exhibit significant tolerance to antimicrobial challenge compared with planktonic bacteria of the same species The antibiofilm activity of a series of 1-alkyl-3-methylimidazolium chloride ionic liquids has been evaluated against a panel of clinically significant microbial pathogens, including MRSA. A comparison of antimicrobial activity against planktonic bacteria and established biofilms is presented. In general, these ionic liquids possess potent, broad spectrum antibiofilm activity.

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