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Communication

Green Chem., 2009, 11, 676 - 679, DOI: 10.1039/b822977e

Combined action of enzymes: the first domino reaction catalyzed by Agaricus bisporus

Heiko Leutbecher, Szilvia Hajdok, Christina Braunberger, Melanie Neumann, Sabine Mika, Jürgen Conrad and Uwe Beifuss

The enzymes tyrosinase and laccase from a crude extract of the button mushroom (Agaricus bisporus) can be employed to catalyze the domino reaction between phenol and various cyclic 1,3-dicarbonyls using atmospheric oxygen as the oxidizing agent and yielding annulated benzofuranes in a highly efficient and sustainable manner.

Graphical abstract image for this article (ID: b822977e)